With China's higher education reform entering the deep water area, private colleges and universities are facing more and more severe problems in personnel training. Colleges and universities have taken measures to deepen the curriculum reform. Taking the college physics experiment course of Changchun University of Architecture and Civil Engineering as an example, this paper expounds the systematic reform measures in the aspects of teaching concept, curriculum system, curriculum content, equipment, teaching mode, means and methods, etc. to give full play to the role of college physics experiment course in cultivating students' comprehensive application ability, engineering practice ability and innovation ability.